Pre-owned / Used 2004 GE HEALTHCARE ÄKTAcrossflow FILTRATION SYSTEMS for Sale

Hardware Summary

Crossflow filtration system with 0.1-1000 kDa MWCO range, 10-100 L/h flow rate, stainless steel housing, 230V/50Hz power, 19" rack-mountable, GE Healthcare engineered for GMP compliance.

Software Summary

GE UNICORN™ control software v7.0+ with 21 CFR Part 11 compliance, real-time monitoring, automated flux optimization, data export to LIMS, audit trail, multi-user access control, touchscr...

Accessories Summary

Compatible with GE hollow-fiber cartridges (UFP-10-C-4MA, UFP-100-C-4MA), pressure sensors, permeate pumps, feed pumps, tubing sets, membrane integrity test kits, and GE-sanctioned calibr...

Hardware

The ÄKTAcrossflow system is a state-of-the-art tangential flow filtration (TFF) platform engineered by GE Healthcare for high-performance bioprocessing applications. The unit features a robust stainless steel chassis with modular crossflow filtration modules, supporting molecular weight cut-off (MWCO) ranges from 0.1 to 1000 kDa, enabling precise separation of proteins, nucleic acids, and viral particles. The system operates with a variable flow rate of 10 to 100 L/h, adjustable via integrated peristaltic pumps, and maintains transmembrane pressure (TMP) up to 6 bar, ensuring optimal flux and yield. The filtration module is housed in a corrosion-resistant 316L stainless steel casing with sanitary tri-clamp connections for seamless integration with downstream processing equipment. The system includes a built-in conductivity sensor (0.01-200 mS/cm range) and temperature probe (-10°C to 80°C), with automatic temperature compensation for consistent performance.

Software / Upgrade / OS / Applications / Worklist

The ÄKTAcrossflow system is powered by GE UNICORN™ software v7.0+, a comprehensive, FDA 21 CFR Part 11-compliant control and data acquisition platform. The software enables fully automated process control, including pre-programmed filtration protocols, flux optimization algorithms, and real-time data logging. Key features include: (1) Multi-parameter monitoring with customizable dashboards for flux, pressure, temperature, and conductivity; (2) Automated membrane integrity testing with pressure hold and diffusion tests; (3) Batch and continuous processing modes with programmable cycle parameters; (4) Data export to LIMS via CSV, XML, or PDF formats, with audit trail functionality for compliance; (5) Multi-user access control with role-based permissions; (6) Remote monitoring and diagnostics via Ethernet/Wi-Fi connectivity; (7) Integration with GE Healthcare’s BioProcess™ suite for seamless data transfer to upstream/downstream bioprocessing systems.

Accessories

The ÄKTAcrossflow system is compatible with a comprehensive range of GE Healthcare accessories and consumables, ensuring optimal performance and longevity. Key accessories include: (1) Hollow-fiber cartridges: GE UFP series with MWCO options of 10 kDa (UFP-10-C-4MA), 100 kDa (UFP-100-C-4MA), 300 kDa (UFP-300-C-4MA), and 1000 kDa (UFP-1000-C-4MA), each with 4.7 m² surface area and 0.5 mm fiber diameter; (2) Pressure sensors: GE Healthcare P-900 series for real-time TMP monitoring; (3) Permeate and feed pumps: Watson-Marlow 520U peristaltic pumps with flow rates up to 20 L/h; (4) Tubing sets: GE Healthcare sanitary tubing kits with 1/4" to 3/8" ID options, USP Class VI certified; (5) Membrane integrity test kits: GE Healthcare’s pressure hold and diffusion test kits for routine validation; (6) Calibration standards: GE Healthcare’s conductivity and pressure calibration kits; (7) Data acquisition modules: GE UNICORN™ compatible DAQ modules for enhanced process monitoring; (8) Mounting ...

Warranty Inclusions & Exclusions

This pre-owned ÄKTAcrossflow system is sold with a comprehensive warranty package designed to provide peace of mind and long-term reliability. The seller offers a 12-month limited warranty covering all mechanical and electrical components, including the filtration module, pumps, sensors, and control system, with the option to extend to 24 months at an additional cost. The warranty includes on-site service for critical failures, remote diagnostics, and replacement of defective parts within 5 business days. Unlimited technical support is provided via phone, email, and remote desktop assistance during business hours. The warranty excludes consumables (e.g., cartridges, tubing) and damage resulting from misuse, improper installation, or unauthorized modifications. Extended maintenance contracts are available, including preventive maintenance visits, calibration services, and software updates.

Service History

This ÄKTAcrossflow system has undergone rigorous refurbishment and validation to ensure optimal performance and compliance with GE Healthcare’s standards. The service history includes: (1) Full disassembly and inspection of all wetted parts, with replacement of seals, O-rings, and membranes; (2) Calibration of all sensors (pressure, conductivity, temperature) to OEM specifications, with certificates traceable to NIST standards; (3) Replacement of peristaltic pump heads and tubing to restore flow accuracy; (4) Upgrade of control software to GE UNICORN™ v7.0+ with 21 CFR Part 11 compliance; (5) Electrical safety testing (IEC 60601-1) and functional verification of all safety interlocks; (6) Performance validation with water flux tests, demonstrating >95% recovery of transmembrane pressure and <5% flux decay over 24-hour operation; (7) Documentation of all service activities, including part numbers, serial numbers, and technician IDs, with traceability to GE Healthcare’s service databa...

Packing List

The ÄKTAcrossflow system is delivered in a custom-engineered, climate-controlled shipping crate designed to protect the unit during transit. The packing list includes: (1) Main unit: ÄKTAcrossflow filtration system with integrated control module, touchscreen interface, and built-in sensors; (2) Power supply: 230V AC power cable with country-specific adapters; (3) Documentation: User manual, service manual, electrical schematic, and quick-start guide; (4) Accessories: GE UFP-100-C-4MA hollow-fiber cartridge (4.7 m², 100 kDa MWCO), pressure sensor (P-900 series), Watson-Marlow 520U peristaltic pump with tubing set, and GE sanitary tubing kit (1/4" ID, 5 ft length); (5) Calibration kit: Conductivity and pressure calibration standards with certificates; (6) Tools: Adjustable wrench, hex keys, and torque screwdriver for maintenance; (7) Spare parts: Set of O-rings, seals, and membrane spacers; (8) Packing materials: Anti-static foam inserts, desiccant packs, and reinforced cardboard oute...

Additional Information

The ÄKTAcrossflow system is a premier tangential flow filtration (TFF) platform designed for high-purity bioprocessing applications, including protein concentration, diafiltration, and viral clearance. Manufactured by GE Healthcare, a global leader in life sciences instrumentation, the system adheres to stringent quality and regulatory standards, including ISO 13485, FDA 21 CFR Part 820 (QSR), and EU MDR 2017/745. The system is CE-marked and 510(k)-exempt, with a Class IIa designation under the EU Medical Device Regulation, making it suitable for clinical and research applications. Key clinical and laboratory applications include: (1) Biopharmaceutical manufacturing: Concentration and purification of monoclonal antibodies, vaccines, and recombinant proteins; (2) Cell therapy: Processing of stem cell-derived products and extracellular vesicles; (3) Gene therapy: Purification of viral vectors and plasmid DNA; (4) Diagnostics: Preparation of clinical samples for molecular assays; (5) Environmental testing: Concentration of pathogens from water or air samples. The system’s compatibility with GE Healthcare’s ÄKTA™ and BioProcess™ platforms enables seamless integration into existing workflows, reducing setup time and improving reproducibility. Performance metrics include a flux stability of ±2% over 24 hours, a transmembrane pressure range of 0.1-6 bar, and a temperature control accuracy of ±0.5°C. The system is compatible with a wide range of buffers and solvents, including PBS, Tris-HCl, and ethanol, with chemical resistance verified for pH 2-12. All wetted parts are USP Class VI and EP 3.1 certified, ensuring biocompatibility for human therapeutic applications. The system’s modular design allows for easy scalability, with options to add additional filtration modules or integrate with GE Healthcare’s single-use technologies. Validation support includes IQ/OQ documentation, with PQ available upon request.